| SPDR | Software Preliminary Design Review | 软件初步设计评审 |
| SPDR | Seattle Purebred Dog Rescue (Seattle, WA) | 西雅图纯种狗救援（西雅图，华盛顿州） |
| SPDR | System Peril Distributed Reflex (Halo 2, Bungie Game Studios) | 系统危险分布式反射（光晕2，邦吉游戏工作室） |
| SPDR | Subcontractor Preliminary Design Review | 分包商初步设计审查 |
| SPDR | Standard & Poor's Depositary Receipts (pronounced \"spider\", symbol SPY) | 标准保管收据(读作“蜘蛛”,象征间谍) |
| SPDR | Seattle Purebred Dog Rescue | 西雅图纯种狗救援 |
| SPDR | System Performance & Design Requirement | 系统的性能和设计要求 |
| SPDR | Secure Protected Development Repository | 安全受保护的开发存储库 |
| SPDR | Standard & Poor's Depository Receipts | 标准的凭证 |
| SPDR | Single Player Demo Release | 单人演示版 |
| SPDR | Spurious-Free Dynamic Range | 无杂散动态范围 |
| SPDR | Split Post Dielectric Resonator | 分裂柱介质谐振器 |