| DEST | Draconis Elite Strike Teams (Battletech) | 龙族精英突击队（Battletech） |
| DEST | Diplôme D'Études SupÉrieures Techniques | Diplôme D'Études SupÉrieures Techniques |
| DEST | Digital Ecosystems and Technologies (conference) | 数字生态系统和技术（会议） |
| DEST | Destroy | 摧毁 |
| DEST | Domestic Emergency Support Team (FBI/FEMA) | 国内的紧急支援小组(联邦调查局FEMA) |
| DEST | Directed Energy Science and Technology | 定向能科学与技术 |
| DEST | Diplôme d'Etudes SupÉrieures Technologiques (French: Technological Higher Education Diploma) | Diplôme d'Etudes SupÉrieures Technologiques (French: Technological Higher Education Diploma) |
| DEST | Department of Education, Science, and Training | 教育、科学和培训部 |
| DEST | Denver Eye Screening Test (Denver Developmental Materials, Inc.) | 丹佛眼科筛查试验（丹佛发展材料公司） |
| DEST | Department of Education, Science and Training (Australia) | 教育、科学和培训部（澳大利亚） |
| DEST | desired thickness | 所需厚度 |
| DEST | denver eye screening test | 丹佛视力筛查试验 |
| DEST | Deaf Enhanced Support Team | 聋人强化支持团队 |
| DEST | Department of the Environment, Sport and Territories (Australia) | 环境、体育和领土部（澳大利亚） |