| DESC | description | 描述 |
| DESC | Digital Equation Solving Computer | 数字方程解算计算机 |
| DESC | descending | 下降 |
| DESC | Deutscher Email Schach Club (German Email Chess Club) | 德国电子邮件沙赫俱乐部（德国电子邮件国际象棋俱乐部） |
| DESC | District Explorer Scout Commissioner (UK) | 地区探险家童军专员（英国） |
| DESC | Diagnose Eliminate Slow And Cancel | 诊断消除缓慢并取消 |
| DESC | Detroit Executive Service Corps (Michigan) | 底特律行政服务团（密歇根州） |
| DESC | Defense Energy Support Center | 国防能源支持中心 |
| DESC | Describe Express Specific Consequences | 描述明确的具体后果 |
| DESC | Defense Electronics Supply Center | 国防电子器材供应中心 |
| DESC | Drainage Erosion and Sediment Control | 排水侵蚀和泥沙控制 |
| DESC | Discover Engineering Summer Camp | 探索工程夏令营 |