| SPX | Sound Production Experience | 声音生成体验 |
| SPX | Sound Production eXtensions | 声音生成扩展 |
| SPX | Sequenced Packet eXchange | 顺序数据包交换 |
| SPX | Standard & Poor's 500 Index | 标准普尔500指数 |
| SPX | Spaceland Airpark (League City, Texas, now defunct) | Spaceland Airpark（德克萨斯州联盟城，现已停用） |
| SPX | Screensaver | 屏幕保护程序 |
| SPX | FoxPro Compiled executable screen file | FoxPro编译的可执行屏幕文件 |
| SPX | Kentrox Soneplex | Kentrox Soneplex公司 |
| SPX | St. Pius X Catholic High School | 圣庇护十世天主教高中 |
| SPX | Small Press Expo | 小型新闻博览会 |