| RLE | Run Length Encoding | 高频次解码 |
| RLE | Repair and Life Extension (ship repair) | 修理和寿命延长（船舶修理） |
| RLE | Right lower extremity | 右下肢 |
| RLE | Run Length Encoded file | 运行长度编码文件 |
| RLE | Required Local Effort | 所需的本地工作 |
| RLE | Bitmap graphics (Utah Run-Length Encoded image file) | 位图图形（犹他州运行长度编码图像文件） |
| RLE | Rat liver epithelial cell | 大鼠肝上皮细胞 |
| RLE | Robert Lee Entertainment | 罗伯特·李娱乐 |
| RLE | Rouelle (French: Lane; Canada Post street designation) | Rouelle（法语：Lane；加拿大邮政街道名称） |
| RLE | Recursive Least Entropy | 递归最小熵 |
| RLE | Right Lower Extremities | 右下肢 |
| RLE | Right-to-Left Embedding | 从右到左嵌入 |
| RLE | Research Laboratory of Electronics at MIT | 麻省理工学院电子研究实验室 |
| RLE | Windows or CompuServe RLE image format | Windows或CompuServe RLE图像格式 |
| RLE | Red Letter Edition | 红色字母版 |