| TLC | tender loving care | 亲切照料、细心看护 |
| TLC | Thin Layer chromatography | 薄层色谱 |
| TLC | Total Lung Capacity | 肺总量 |
| TLC | The Lobster Conservancy (Friendship, ME) | 龙虾保护协会（友谊，ME） |
| TLC | The Learning Channel | 学习渠道 |
| TLC | Tratado de Libre Comercio | 自由商业交易 |
| TLC | Technology Life Careers | 技术生活职业 |
| TLC | Transformation Life Cycle | 转型生命周期 |
| TLC | TransLogistique, Canada (Logistics and SCM training) | 加拿大TransLogistique（物流和SCM培训） |
| TLC | Tennessee Llama Community | 田纳西州Llama社区 |
| TLC | Transportation & Logistics Council, Inc. (formerly Transportation Consumer Protection Council, TCPC) | 省、自治区、直辖市人民政府交通运输和物流公司。(从前运输消费者保护委员会,TCPC) |
| TLC | Transformational Learning Connections | 转变性学习联系 |
| TLC | Test Loop Combination | 测试回路组合 |
| TLC | The Lego Company | 乐高公司 |
| TLC | Three Letter Code | 三字母代码 |
| TLC | Trichotillomania Learning Center (Santa Cruz, CA) | 拔毛症学习中心（加利福尼亚州圣克鲁斯） |
| TLC | Trades and Labor Council of Western Australia | 西澳州贸易和劳工委员会 |
| TLC | total lymphocyte count | 总淋巴细胞计数 |
| TLC | Toastmasters Learning Center | 演讲会学习中心 |
| TLC | Total Logistic Control | 总体物流控制 |
| TLC | Therapeutic Lifestyle Change | 治疗性生活方式改变 |
| TLC | Traffic Load Control | 交通负荷控制 |
| TLC | The Lost Creatures (gaming clan) | 失落的生物（游戏部落） |
| TLC | Targeted Learning Corporation | 目标学习公司 |
| TLC | The Learning Collaborative (Columbia, South Carolina) | 学习协作组织（哥伦比亚，南卡罗来纳州） |
| TLC | The Last Crusade (Indiana Jones movie) | 最后的十字军东征（印第安纳琼斯电影） |
| TLC | Tough Logging Conditions (oil industry) | 恶劣的伐木条件（石油行业） |
| TLC | Tender Loving Cuisine (Five Dock, NSW, Australia) | 柔情美食（澳大利亚新南威尔士州五码头） |
| TLC | Triple-Lumen Catheter | 三腔导管 |
| TLC | Trafikledningscentral | 交通场景 |
| TLC | Texas Lutheran College | 德克萨斯路德学院 |
| TLC | Tactical Landing Craft | 战术登陆艇 |
| TLC | Thermochromic Liquid Crystal | 热致变色液晶 |
| TLC | Touro Law Center | 图罗法律中心 |
| TLC | Tuckerton Lumber Company | 塔克顿木材公司 |
| TLC | The Leaky Cauldron (Harry Potter website) | 《破釜》（哈利·波特网站） |
| TLC | Total Loss of Capacity (SDH or Sonet Technology) | 总容量损失（SDH或Sonet技术） |
| TLC | Transitional Line Charge | 过渡线路充电 |
| TLC | Telecommunication Line Controller | 电信线路控制器 |
| TLC | The Leadership Center | 领导力中心 |
| TLC | The Laughing Classroom (book) | 笑教室（书） |
| TLC | Teen Leadership Conference | 青少年领导力会议 |
| TLC | The Life Cycle Cost Company Ltd (UK) | 生命周期成本公司（英国） |
| TLC | Total Leucocyte Count | 总白细胞计数 |
| TLC | Texas Logistics Corporation | 德克萨斯物流公司 |
| TLC | Transport Logical Connection (Ciena) | 传输逻辑连接（Ciena） |
| TLC | Total Lateral Clearance (highway capacity, civil engineering) | 总横向净空（公路通行能力、土木工程） |
| TLC | Tastes Like Chicken | 尝起来像鸡肉 |
| TLC | Tasty Little Chewies (Kashi Company) | 美味小咀嚼（喀什公司） |
| TLC | Tripp Lake Camp (Poland, Maine) | 特里普湖营地（波兰、缅因州） |
| TLC | Transitional Learning Center | 过渡学习中心 |
| TLC | Trunk Logic Circuit (Nortel) | 干线逻辑电路（北电） |
| TLC | Tasty Little Crackers (Kashi Company) | 美味小饼干（喀什公司） |
| TLC | Teaching and Learning Centre (Australia) | 教学中心（澳大利亚） |
| TLC | Teacher Leadership Council (Mormon Church) | 教师领导委员会（摩门教） |
| TLC | Teen Life Conference | 青少年生活会议 |
| TLC | Territory Logistics Center (FEMA) | 领地物流中心（FEMA） |
| TLC | Toxic Links Coalition | 有毒链接联盟 |
| TLC | Technology Learning Center | 技术学习中心 |
| TLC | Tailored Logistics Corporation (defense contractor specializing in the development of component overhaul kits) | 定制物流公司（专门开发部件检修套件的国防承包商） |
| TLC | The Learning Company | 学习型公司 |
| TLC | Toyota Land Cruiser | 丰田陆地巡洋舰 |
| TLC | Teaching/Learning Center | 教学/学习中心 |
| TLC | The Laser Center (laser vision correction) | 激光中心（激光视力矫正） |
| TLC | Transmission Line Coupler | 传输线耦合器 |
| TLC | Technology Life Cycle | 技术生命周期 |
| TLC | The Loveline Companion | 可爱的伴侣 |
| TLC | Trivial Loot Code (Everquest game) | 琐碎的抢劫代码（Everquest游戏） |
| TLC | Total Lack of Consideration | 完全缺乏考虑 |
| TLC | Telephone Line Control | 电话线控制 |
| TLC | Tech Logic Corporation (library services company) | 技术逻辑公司（图书馆服务公司） |
| TLC | Toys for Local Children (charity) | 当地儿童玩具（慈善机构） |
| TLC | Team Life Care Insurance Pvt Ltd (India) | Team Life Care Insurance Pvt Ltd（印度） |
| TLC | Trinity Lutheran College | 三一路德学院 |
| TLC | The Library Corporation | 图书馆公司 |
| TLC | Tiwi Land Council (statutory authority representing Aboriginal Owners of Tiwi Islands) | 蒂维土地委员会（代表蒂维群岛原住民所有者的法定机构） |
| TLC | TrueLicense Library Collection | TrueLicense库集合 |
| TLC | TACOM (Tank-Automotive and Armaments Command) Learning Center | TACOM（坦克汽车和装备司令部）学习中心 |
| TLC | Thunderbird Language Center (AGSIM, Glendale, AZ, USA) | 雷鸟语言中心（美国亚利桑那州格伦代尔AGSIM） |
| TLC | Transformative Learning Centre (Ontario Institute for Studies in Education, University of Toronto) | 转型学习中心（多伦多大学安大略教育研究所） |
| TLC | Ternary Linear Code | 三元线性码 |
| TLC | Trac Lapping Club | Trac Lapping俱乐部 |
| TLC | Team Leadership Center | 团队领导中心 |
| TLC | Trotskyist League of Canada | 加拿大托洛茨基主义联盟 |
| TLC | Tables & Ladders & Chairs (pro wrestling) | 表和梯子和椅子(职业摔跤) |
| TLC | Tomatoes, Lettuce, and Cheese | 番茄、生菜和奶酪 |
| TLC | Texas Land & Cattle (restaurant) | 德州土地和牛(餐厅) |
| TLC | Transgender Liberation and Care | 跨性别解放和关怀 |
| TLC | The Living Church | 活教会 |
| TLC | Two Letter Clan (gaming clan) | 双字母氏族（游戏氏族） |
| TLC | Total Lines of Code | 代码行总数 |
| TLC | Truth in Labeling Campaign | 标签运动中的真相 |
| TLC | Translunar Coast | Transunar海岸 |
| TLC | Transportation for Livable Communities | 宜居社区交通 |
| TLC | Tender Love and Care (song) | 温柔的爱与关怀（歌曲） |
| TLC | T-Boz, Left Eye, & Chili (the band TLC) | T-Boz,左眼,及辣椒(乐队TLC) |
| TLC | Telecomunicazioni | 远程通信 |
| TLC | The Latino Coalition (Washington, DC) | 拉丁裔联盟（华盛顿特区） |
| TLC | Transformer-rectifier Line Contactor | 变压器整流器线路接触器 |