| ISS | I Said So | 我是这样说的 |
| ISS | International Space Station | 国际空间站 |
| ISS | Internet Security Systems | 互联网安全系统 |
| ISS | Ionosphere Sounding Satellite | 电离层探测卫星 |
| ISS | International Survivalist Society | 国际幸存者协会 |
| ISS | Iron and Steel Society | 钢铁协会 |
| ISS | Information Systems Squadron | 信息系统中队 |
| ISS | Istituto Superiore di SanitÀ (Italian National Institute of Health) | Istituto Superiore di SanitÀ (Italian National Institute of Health) |
| ISS | Internet Security Systems, Inc. | 互联网安全系统公司。 |
| ISS | International Switching Symposium | 国际交换研讨会 |
| ISS | Infrared Surveillance Sensor | 红外监视传感器 |
| ISS | Integrated Space Systems | 综合空间系统 |
| ISS | Imposto Sobre Serviços (Brazilian tax) | Imposto Sobre Serviços (Brazilian tax) |
| ISS | International Society of Surgery | 国际外科学会 |
| ISS | Information Superiority and Sensors | 信息优势与传感器 |
| ISS | Interactive Survivability Simulation | 交互式生存能力仿真 |
| ISS | Information Services and Systems | 信息服务和系统 |
| ISS | Intermediate Service School | 中级服务学校 |
| ISS | International Seismological Summary | 国际地震概要 |
| ISS | Information Systems Services | 信息系统服务 |
| ISS | Information and Systems Society | 信息与系统社会 |
| ISS | InfraStructure Systems GmbH (Hanover, Germany) | InfraStructure Systems GmbH（德国汉诺威） |
| ISS | Islands | 群岛 |
| ISS | Interactive Support System | 交互式支持系统 |
| ISS | Internal Secondary Structure | 内部二级结构 |
| ISS | Instrument Sales and Service, Inc. | 仪器销售和服务公司。 |
| ISS | Institute of Social Sciences | 社会科学研究所 |
| ISS | Impedance Standard Substrate | 阻抗标准基板 |
| ISS | Intelligence Support Squadron | 情报支援中队 |
| ISS | Inside Surface | 内表面 |
| ISS | Internet Security Scanner | Internet安全扫描程序 |
| ISS | Instrument Support Structure | 仪表支撑结构 |
| ISS | Issue | 问题 |
| ISS | Inter-Satellite Service | 卫星间服务 |
| ISS | Isotonic Saline Solution | 等渗盐水溶液 |
| ISS | Institute of Space Science | 空间科学研究所 |
| ISS | International Supply Services (Portsmouth, VA) | 国际供应服务（弗吉尼亚州朴茨茅斯） |
| ISS | International Sanitary Systems | 国际卫生系统 |
| ISS | Information Security Services | 信息安全服务 |
| ISS | Instructional Support System | 教学支持系统 |
| ISS | Ion Scattering Spectrometry | 离子散射光谱法 |
| ISS | International Sales Support | 国际销售支持 |
| ISS | Image Stabilization System | 图像稳定系统 |
| ISS | International Soccer Superstar (video game) | 国际足球巨星（电子游戏） |
| ISS | Imperial Star Ship (Star Trek) | 帝国星舰（星际旅行） |
| ISS | Immunization Services Support (WHO) | 免疫服务支持（世界卫生组织） |
| ISS | Image Server System | 图像服务器系统 |
| ISS | Internal Secondary Storage | 内部辅助存储 |
| ISS | Institute of Somatic Sciences | 躯体科学研究所 |
| ISS | Integrated SS7 Signaling | 集成SS7信令 |
| ISS | I'm So Sure | 我很有把握 |
| ISS | Integrated Service Solutions | 集成服务解决方案 |
| ISS | In-Service Support | 现役支援 |
| ISS | International Scoring Systems (Paris, France) | 国际评分系统（法国巴黎） |
| ISS | Integrated Survey System | 综合测量系统 |
| ISS | Investment Statistical System | 投资统计系统 |
| ISS | Integrated System Support | 集成系统支持 |
| ISS | Integrated Start System | 集成启动系统 |
| ISS | Interim Supply Support | 临时供给支援 |
| ISS | Initial (Execution) Sequence Set | 初始（执行）序列集 |
| ISS | Instituto de Seguros Sociales (Colombia) | 社会科学研究所（哥伦比亚） |
| ISS | Intel Solution Services | 英特尔解决方案服务 |
| ISS | In-School Suspension | 在校期间休学 |
| ISS | Institutional Shareholder Services | 机构股东服务 |
| ISS | Instruction Set Simulator | 指令集模拟器 |
| ISS | Independent School Services | 独立学校服务 |
| ISS | Institute for Security Studies | 安全研究所 |
| ISS | Imaging Science Subsystem (NASA Cassini mission) | 成像科学子系统（NASA卡西尼号任务） |
| ISS | Institute of Statistical Science | 统计科学研究所 |
| ISS | Internet Sharing Server | Internet共享服务器 |
| ISS | Injury Severity Score | 伤害严重程度评分 |
| ISS | Integrated Systems Solutions | 集成系统解决方案 |
| ISS | International Skeletal Society | 国际骨骼学会 |
| ISS | Incoming Signal Strength | 输入信号强度 |
| ISS | Intelligence Systems Secretariat | 情报系统秘书处 |
| ISS | Information Sharing Session | 信息共享会话 |
| ISS | Intelligent Software Solutions, Inc (Raleigh, North Carolina) | 智能软件解决方案公司（北卡罗来纳州罗利） |
| ISS | Information Systems Security | 信息系统安全 |
| ISS | Institute for State Studies | 国家研究所 |
| ISS | Integrated Sounding System | 综合探测系统 |
| ISS | Ion Scattering Spectroscopy | 离子散射光谱学 |
| ISS | Infinite Server Station | 无限服务器站 |
| ISS | IAIPS Support Services | IAIPS支持服务 |
| ISS | Intelligent Server Switch (Apache) | 智能服务器交换机（Apache） |
| ISS | Instant Start System | 即时启动系统 |
| ISS | Interactive Selling System | 交互式销售系统 |
| ISS | Integrated Sealift Study | 综合海上补给研究 |
| ISS | Integrated Sensor System | 集成传感器系统 |
| ISS | Isotope Separation System | 同位素分离系统 |
| ISS | Iransk-Svenska Solidaritetsföreningen | Iransk-Svenska Solidaritetsföreningen |
| ISS | Information Systems Staff | 信息系统员工 |
| ISS | Interservice Supply Support | 军种间供应支持 |
| ISS | Input Sub System | 输入子系统 |
| ISS | Information Systems Support, Inc | 信息系统支持公司 |
| ISS | Infusion Signaling Server | 输液信号服务器 |
| ISS | Integrated Support Service | 综合支持服务 |
| ISS | Integrated Safety System | 综合安全系统 |
| ISS | Integrated System Schedule | 综合系统计划 |
| ISS | Indirect/Inertial Subsystem | 间接/惯性子系统 |
| ISS | International School of Singapore | 新加坡国际学校 |