| SPF | sun protection factor | 防晒系数 |
| SPF | Sphase promoting factor | 促S期因子 |
| SPF | spare parts financing | 零部件融资 |
| SPF | Service Port Function | 业务口功能 |
| SPF | Subscriber Plant Factor | 用户工厂系数 |
| SPF | Sun Protection Factor (sun block rating) | 防晒系数（防晒等级） |
| SPF | Single Point Failure | 单点故障 |
| SPF | Space Power Facility (NASA) | 太空动力设施（NASA） |
| SPF | Strategic Prevention Framework (US federal grant program) | 战略预防框架（美国联邦拨款计划） |
| SPF | Sodium Process Facility | 钠处理设施 |
| SPF | Software Production Facility (NASA) | 软件生产设施（NASA） |
| SPF | Shipper Paid Forwarding (US Postal Service program for payments) | 发货人付费转发（美国邮政服务付款计划） |
| SPF | Signal Processing Facility | 信号处理设施 |
| SPF | Standard Project Flood | 标准项目洪水 |
| SPF | Sender Policy Framework (antispam initiative) | 发件人策略框架（反垃圾邮件计划） |
| SPF | Sensor Fusion Post | 传感器融合柱 |
| SPF | Structured Programming Facility | 结构化编程设施 |
| SPF | Science Policy Foundation (United Kingdom) | 科学政策基金会（英国） |
| SPF | Site Population Factor | 现场人口因素 |
| SPF | Service Public FÉdÉral (Belgium) | Service Public FÉdÉral (Belgium) |
| SPF | Standard Pacific Corporation (stock symbol) | 标准太平洋公司（股票符号） |
| SPF | Special Purpose Force | 特种部队 |
| SPF | SmartPlant Foundation (Intergraph) | SmartPlant基金会（Intergraph） |
| SPF | SIDPERS Personnel File | SIDPERS人员档案 |
| SPF | Security Police Flight | 安全警察航班 |
| SPF | Superplastic Forming (metallurgy) | 超塑性成形（冶金） |
| SPF | Special Programs File | 特殊程序文件 |
| SPF | Super Frame (ITU-T) | 超级帧（ITU-T） |
| SPF | Spray-applied Polyurethane Foam | 喷涂聚氨酯泡沫 |
| SPF | Swiss Peace Foundation | 瑞士和平基金会 |
| SPF | Synthetic Phase Fraction | 合成相分数 |
| SPF | Strategic Projection Force | 战略预测部队 |
| SPF | Stile Project Forum | Stile项目论坛 |
| SPF | Standard Plume Flowfield code | 标准羽流场代码 |
| SPF | Stair Pressurization Fan (mechanical services) | 楼梯增压风机（机械服务） |
| SPF | Slide Presentation File (EnerGraphics file extension) | 幻灯片演示文件（EnerGraphics文件扩展名） |
| SPF | Single Point of Filing | 单点归档 |
| SPF | Servicio Penitenciario Federal (Spanish; Argentina) | Servicio Penitenciario Federal（西班牙语；阿根廷） |
| SPF | Stealthy Packet Filter (Firewall) | 隐形数据包过滤器（防火墙） |
| SPF | Sunbelt Personal Firewall | Sunbelt个人防火墙 |
| SPF | Sale Pending Funds | 待出售资金 |
| SPF | Sygate Personal Firewall | Sygate个人防火墙 |
| SPF | Scientific Primates Filipinas, Inc | 菲律宾灵长类科学公司 |
| SPF | Secours Populaire Français | Secours Populaire Français |
| SPF | skin protection factor | 皮肤保护系数 |
| SPF | Spare Parts File | 备件文件 |
| SPF | Shortest Path First | 最短路径优先 |
| SPF | Special Function Memory | 特殊功能存储器 |
| SPF | Specific Pathogen Free | 无特定病原体 |
| SPF | Single Project Funded | 单一项目融资 |
| SPF | Spruce Pine Fir | 云杉冷杉 |
| SPF | Signal on Protection Fiber | 保护光纤上的信号 |
| SPF | South Pacific Forum | 南太平洋论坛 |
| SPF | Standard Parasitic Format | 标准寄生格式 |
| SPF | Singapore Police Force | 新加坡警察部队 |
| SPF | Specialist Portfolio (New York Stock Exchange) | 专业投资组合（纽约证券交易所） |
| SPF | superfine | 超精细的 |
| SPF | Skagitonians to Preserve Farmland (Mount Vernon, WA) | 斯卡吉顿人保护农田（华盛顿州弗农山） |
| SPF | Sender Permitted From (email; now Sender Policy Framework) | 允许发件人（电子邮件；现在为发件人策略框架） |
| SPF | Sold Pending Funds | 已售出待定资金 |
| SPF | Servicio PÚblico Federal (Mexico) | Servicio PÚblico Federal (Mexico) |
| SPF | suntan photoprotection factor | 日晒防护因子 |
| SPF | specified-pathogens free | 无特定病原体 |
| SPF | specific-pathogen free | 无特定病原体 |
| SPF | streptococcal proliferative factor | 链球菌增殖因子 |
| SPF | Special Performance File | 特殊性能文件 |
| SPF | Sphincter Pucker Factor | 括约肌折叠因子 |
| SPF | System Programming Facility | 系统编程设施 |
| SPF | System Productivity Facility (system used in TSO to create and edit data) | 系统生产力设施（TSO中用于创建和编辑数据的系统） |
| SPF | Summertime Phone Functionality | 夏季手机功能 |
| SPF | S&P Food Industries (Malaysia) | 食品行业标准(马来西亚) |
| SPF | Serious Pennsy Fan | 严肃的Pennsy风扇 |
| SPF | Slide Presentation File | 幻灯片演示文稿文件 |
| SPF | split products of fibrin | 纤维蛋白分裂产物 |
| SPF | spectrophotofluorometer | 荧光分光光度计 |
| SPF | Sender Permitted From | 允许发件人 |
| SPF | spectrofluorometry | 荧光分光光度法 |
| SPF | Standard Pacific Corporation | 标准太平洋公司 |
| SPF | Sunscreen Protection Factor | 防晒保护系数 |
| SPF | Sizzle People Fast | 快速刺激人们 |
| SPF | Single Project Funding | 单一项目资金 |