| SPIKE | Student's Personal Integrated Knowledge Environment | 学生的个人综合知识的环境 |
| SPIKE | Specially Prepared Individuals for Key Events | 为关键活动特别准备的个人 |
| SPIKE | Science Planning Interactive Knowledge Environment (Hubble Telescope data processor) | 科学规划交互式知识环境（哈勃望远镜数据处理器） |
| SPIKE | Science Planning Intelligent Knowledge-Based Environment | 科学规划智能知识环境 |
| SPIKE | Spike's Personality Is Kinda Evil | 狼牙的个性很邪恶 |
| SPIKE | Students Personal Integrated Knowledge Environment | 学生个人综合知识环境 |