| USC | United States Congress | 美国国会 |
| USC | United States Code | 美国法典 |
| USC | User Service Center | 用户服务中心 |
| USC | Upper St. Clair (Township, Pennsylvania) | 上圣克莱尔（宾夕法尼亚州乡镇） |
| USC | Ultra Software Corporation | Ultra软件公司 |
| USC | Ultra Sonic Cleaning | 超声波清洗 |
| USC | Ultra Super Critical (Technologies) | 超临界（技术） |
| USC | United Somali Congress (political party) | 索马里联合大会（政党） |
| USC | Under Separate Cover | 在单独的封面下 |
| USC | Unified Soil Classification | 统一土壤分类 |
| USC | Uterine Serous Carcinoma | 子宫浆液癌 |
| USC | UniÓn Social Cristiana (Spanish: Social Christian Union, El Salvador) | UniÓn Social Cristiana (Spanish: Social Christian Union, El Salvador) |
| USC | Underground Service Cable (power distribution) | 地下服务电缆（配电） |
| USC | United Sugar Company | 联合糖业公司 |
| USC | University of Southern California | 南加州大学 |
| USC | United States Champion | 美国冠军 |
| USC | USAREUR Subordinate Command | USAREUR下属司令部 |
| USC | United States Constitution | 美国宪法 |
| USC | United States Citizen | 美国公民 |
| USC | The University Of South Central | 中南大学 |
| USC | The University Of Steroids And Creatine | 类固醇和肌酸大学 |
| USC | University of Second Choice | 第二选择大学 |
| USC | UniÓn Socialista de Cataluña | UniÓn Socialista de Cataluña |
| USC | University of Spoiled Children | 被宠坏了的孩子的大学 |
| USC | United States of Consciousness | 意识美国 |
| USC | United Sol Confederation | 索尔联合会 |
| USC | University Students Council | 大学生理事会 |
| USC | The University Of Southern California | 南加州大学 |
| USC | Unequally Shared Channel (channel reservation scheme) | 不等共享信道（信道预留方案） |
| USC | Undoubtedly Screwed College | 毫无疑问，这所大学很糟糕 |
| USC | United States Court | 美国法院 |
| USC | Underground Serbian Cafe | 地下塞尔维亚咖啡馆 |
| USC | U S Can Corporation | 美国罐头公司 |
| USC | undifferentiated stem cell | 未分化干细胞 |
| USC | University of Service and Compassion | 服务与同情大学 |
| USC | ultrasonic cleaning | 超声波清洗 |
| USC | Unexplainable Social Calamity | 无法解释的社会灾难 |
| USC | unseparated cell | 未分离细胞 |
| USC | University of Snobbish Children | Snobbish儿童大学 |
| USC | Unified Speech Codec | 统一语音编解码器 |
| USC | University Senior College | 大学高级学院 |
| USC | Ultimate Stag Challenge | 终极雄鹿挑战赛 |
| USC | United States Cavalry | 美国骑兵队 |
| USC | Using Service Code | 使用服务代码 |
| USC | University of Santiago de Compostela (Spain) | 圣地亚哥德孔波斯特拉大学（西班牙） |
| USC | University of San Carlos | 聖卡洛斯大學 |
| USC | United States Census | 美国人口普查 |
| USC | University of the Sunshine Coast (Queensland, Australia) | 阳光海岸大学（澳大利亚昆士兰州） |
| USC | Unit Shipping Container | 单位装运集装箱 |
| USC | University of Southern Colorado (now Colorado State University-Pueblo; Pueblo, Colorado USA) | 南科罗拉多大学（现为科罗拉多州立大学普韦布洛分校；美国科罗拉多州普韦布洛） |
| USC | Universal Service Card | 通用服务卡 |
| USC | Universidad Santiago de Cali (Spanish) | 圣地亚哥卡利大学（西班牙语） |
| USC | Up Stage Center | 舞台上中心 |
| USC | Uniformly Stable Conformal | 一致稳定共形 |
| USC | Urban Street Canyon | 城市街道峡谷 |
| USC | Utrechtsch Studenten Corps (NL) | 乌得勒支学生军团（NL） |
| USC | Urban Services Committee | 市政委员会 |
| USC | universal service contract (US DoD) | 通用服务合同（美国国防部） |
| USC | Urzad Stanu Cywilnego | 乌尔扎德·斯坦努·西维尔内戈 |
| USC | University of San Carlos (Cebu City, Philippines) | 圣卡洛斯大学（菲律宾宿务市） |
| USC | Universitäts Sport Club (German: University Sports Club) | Universitäts Sport Club (German: University Sports Club) |
| USC | US Can Corporation (stock symbol) | 美国罐头公司（股票符号） |
| USC | Unione Sanguis Christi (Sanguis Christi Union) | 基督教圣会联合会（基督教圣会联盟） |
| USC | Universal Service Code | 通用服务代码 |
| USC | United States Cavers (forum) | 美国洞穴（论坛） |
| USC | Universidade de Santiago de Compostela (Spain) | 圣地亚哥德孔波斯特拉大学（西班牙） |
| USC | US Cryogenics (Nashville, Tennessee) | 美国低温（田纳西州纳什维尔） |