| HISC | Hydrogen Induced Stress Cracking | 氢致应力开裂 |
| HISC | Home Instead Senior Care | 居家养老 |
| HISC | House Internal Security Committee | 众议院内部安全委员会 |
| HISC | Health Information Solutions Centre (Canada) | 健康信息解决方案中心（加拿大） |
| HISC | Hawaii Invasive Species Council | 夏威夷入侵物种委员会 |
| HISC | High-density Instruction Set Computer | 高密度指令集计算机 |