| OPAL | Open Physics Abstraction Layer | 开放物理抽象层 |
| OPAL | Officer Promotion Authorization Listing | 高管晋升授权清单 |
| OPAL | Optical Program Algorithm | 光学程序算法 |
| OPAL | Object Process Alignment | 对象流程对齐 |
| OPAL | Optical Access Lines (Deutsche Telekom) | 光接入线（德国电信） |
| OPAL | Open Pool Australian Light-Water (reactor) | 开放池澳大利亚轻水（反应堆） |
| OPAL | Optimal Aging & Longevity (Houston, TX clinic) | 最佳的老化和长寿(德克萨斯州的休斯顿,诊所) |
| OPAL | Open Phone Abstraction Library | 打开电话摘要库 |
| OPAL | Option Action List | 选项操作列表 |
| OPAL | Oracle, PHP, Apache and Linux | Oracle、PHP、Apache和Linux |
| OPAL | Optical Armament Link | 光学武器链路 |
| OPAL | Operation Progress and Alert | 操作进度和警报 |
| OPAL | Omni-Purpose Apparatus for LEP (experiment at the CERN physics laboratory) | LEP通用仪器（CERN物理实验室实验） |
| OPAL | Orchestration and Provisioning Automation Library (IBM) | 业务流程和资源调配自动化库（IBM） |
| OPAL | Optical Platform Alignment Linkage | 光学平台校准仪器 |
| OPAL | Outstanding Projects and Leaders (ASCE Award) | 杰出项目和领导者（ASCE奖） |
| OPAL | Outfitting Publication Applicability List | 装备出版物适用性列表 |
| OPAL | Organized Parents Against Lead | 有组织的家长反对铅 |