| MESS | Messapic (linguistics) | Messapic（语言学） |
| MESS | Maintenance of Electronic Super Sonics | 电子超音速的维护 |
| MESS | Multi-Emulator Super System (computer program that emulates early home computers and video games) | 多仿真器超级系统（模拟早期家用计算机和视频游戏的计算机程序） |
| MESS | Multi Engine Search Script | 多引擎搜索脚本 |
| MESS | Mesoscale and Severe Storms Computer System | 中尺度和强风暴计算机系统 |
| MESS | Model Evaluation Support System | 模型评估支持系统 |
| MESS | Maintenance Engineering Support Services | 维护工程支持服务 |
| MESS | Multi Emulator Super System | 多仿真器超级系统 |
| MESS | Multiple Emulator Super System | 多仿真器超级系统 |
| MESS | Maximum Effective Sonar Speed | 声呐最大有效测速 |
| MESS | Mike's Electronic Support System | 迈克的电子支持系统 |
| MESS | MinistÈre de l'Enseignement SupÉrieur et de la Science | MinistÈre de l'Enseignement SupÉrieur et de la Science |
| MESS | Metal Sanayicileri Sendikasý (Turkish: Metal Industrialists' Union) | Metal Sanayicileri Sendikasý (Turkish: Metal Industrialists' Union) |
| MESS | Menhir's Econometric Simulation System | Menhir的计量仿真系统 |
| MESS | Marvelous Explorations Through Science and Stories | 科学与故事的奇妙探索 |
| MESS | Mangled Extremity Severity Score | 四肢损伤严重程度评分 |
| MESS | Ministry of Education, Science and Sport (Sweden) | 教育、科学和体育部（瑞典） |
| MESS | Mechanical and Electrical Subsystem Simulator (Mariner IV mission) | 机电子系统模拟器（水手四号任务） |