| ISAM | Intelligent Services Access Manager | 智能服务访问管理器 |
| ISAM | Information Centre for Southern African Music | 南部非洲音乐信息中心 |
| ISAM | Infant of a Substance Abusing Mother | 滥用药物母亲的婴儿 |
| ISAM | First Samuel | 第一塞缪尔 |
| ISAM | Integrated Switching And Multiplexing | 集成交换和多路复用 |
| ISAM | Information Security Awareness Month | 信息安全意识月 |
| ISAM | International Symposium on Advanced Materials | 先进材料国际研讨会 |
| ISAM | Intermediate Software Acquisition Management Course (IRMC/DSMC, also known as SAM 201) | 中级软件采集管理课程(IRMC /出发,也称为山姆201) |
| ISAM | International Symposium on Assembly and Manufacturing | 装配与制造国际研讨会 |
| ISAM | International Society for Aerosols in Medicine | 国际医学气溶胶学会 |
| ISAM | Indexed Sequential Access Method | 索引顺序访问方法 |
| ISAM | Ionic Self-Assembled Monolayer | 离子自组装单层 |
| ISAM | Institute for Studies in American Music (Brooklyn College, City University of New York) | 美国音乐研究所（纽约城市大学布鲁克林学院） |