| MOST | the Ministry of Science and Technology | 科技部 |
| MOST | Ministry of Science and Technology of the People's Republic of China | 中华人民共和国科学技术部 |
| MOST | Metal-Oxide-Semiconductor Transistor | 金属-氧化物半导体晶体管 |
| MOST | Maynard Operation Sequence Technique | 梅纳德操作排序技术 |
| MOST | Media Oriented Systems Transport | 媒体导向系统运输 |
| MOST | Management of Science & Technology | 高科技管理 |
| MOST | Ministry of Science and Technology of the People's Republic of China | 中华人民共和国科学技术部 |
| MOST | Metal Oxide Semiconductor Transistor | 金属氧化物半导体晶体管 |
| MOST | Ministry of Science and Technology | 科学技术部 |
| MOST | Mission Operations Support Team | 任务运营支持团队 |
| MOST | Multidisciplinary Optical Switching Technology | 多学科光交换技术 |
| MOST | Molonglo Observatory Synthesis Telescope | 莫隆洛天文台综合望远镜 |
| MOST | Museum of Science and Technology | 科学技术博物馆 |
| MOST | Mobile Open Systems Technologies | 移动开放系统技术 |
| MOST | MTL Open System Technologies | MTL开放系统技术 |
| MOST | Marine Observing Systems Team | 海洋观测系统小组 |
| MOST | Multipulse Observation Sizing Technique | 多脉冲观测定径技术 |
| MOST | Monitoring Observation Surveillance Targeting (NATO, field teams in Bosnia and Herzegovina) | 监测观察监视目标（北约、波斯尼亚和黑塞哥维那实地小组） |
| MOST | Modeling and Observing for Substitute Teaching | 替代教学的建模与观察 |
| MOST | Multimedia On-Line Service Technologies (Israel) | 多媒体在线服务技术（以色列） |
| MOST | Maintenance Optimization Support and Training | 维护优化支持和培训 |
| MOST | Municipal Option Sales Tax | 市政期权销售税 |
| MOST | Market Order System of Trading | 交易市场秩序体系 |
| MOST | Motorcycle Operator's Skill Test | 摩托车操作员的技能测试 |
| MOST | Mission Oriented System Tape | 完成任务所需的系统带 |
| MOST | Mobile Sonar Technology | 移动式声呐技术 |
| MOST | Media Oriented System Transport | 面向媒体的系统传输 |
| MOST | Maximizing Out-of-School Time | 最大化校外时间 |
| MOST | Microvariability and Oscillations of Stars (Canadian built orbiting telescope) | 恒星的微变率和振荡（加拿大建造的轨道望远镜） |
| MOST | Mobile Optical Surveillance Tracker | 移动式光学监视跟踪器 |
| MOST | Ministry Of Silly Talks | 愚蠢的谈话部 |
| MOST | Mission Oriented Simulator Training | 面向任务的模拟器培训 |
| MOST | Microvariability Oscillations of STars | STar的微变率振荡 |
| MOST | Method Of Splitting Tsunami | 分割海啸的方法 |
| MOST | Management of Social Transformations Programme | 社会转型计划管理 |
| MOST | Museum of South Texas History (formerly Hidalgo County Historical Museum; Edinburg, Texas) | 南德克萨斯州历史博物馆（原伊达尔戈县历史博物馆；德克萨斯州埃丁堡） |
| MOST | Management Of Social Transformation | 社会转型管理 |
| MOST | Media Oriented System Transfer | 面向媒体的系统传输 |
| MOST | Mosaic Optical Sensor Technology | 马赛克光学传感器技术 |
| MOST | Mobilization Optimization Stabilization and Training | 动员优化、稳定和培训 |
| MOST | Multispectral Observations of Storm Tops | 风暴顶的多光谱观测 |
| MOST | Mothers Of Super- Twins | 超级双胞胎的母亲 |
| MOST | Mobile Over Snow Transport | 移动式雪地运输 |