| CUBE | Council of Urban Boards of Education (National School Boards Association) | 城市教育委员会委员会（全国学校委员会协会） |
| CUBE | C Cube Microsystems, Inc. | C Cube Microsystems公司。 |
| CUBE | Centre for the Understanding of the Built Environment (Liverpool, UK) | 建筑环境理解中心（英国利物浦） |
| CUBE | C2 Unified Battlespace Environment | C2统一作战空间环境 |
| CUBE | Credit Union Business Environment (Fiserv software) | 信用社商业环境（Fiserv软件） |
| CUBE | Cambridge Unit for Bioscience Engineering | 剑桥生物科学工程单位 |
| CUBE | Computer Use by Engineers | 工程师使用计算机 |
| CUBE | Conceptual Understanding Through Blind Evaluation | 通过盲评估进行概念理解 |
| CUBE | Command and Control Unified Battlespace Environment | 指挥与控制统一战场环境 |
| CUBE | Combined Uncertainty and Bathymetry Estimation | 综合不确定度和水深估计 |