| ISAAC | Interdistrict School for Arts and Communication | 区际艺术与传播学校 |
| ISAAC | International Society for Augmentative and Alternative Communication | 国际增强和替代通信学会 |
| ISAAC | Integrated Synchronous and Asynchronous Collaboration | 集成的同步和异步协作 |
| ISAAC | International Symposium on Algorithms and Computation | 国际算法与计算研讨会 |
| ISAAC | ImmunoSpot Array Assay on Chip | 芯片免疫斑点阵列分析 |
| ISAAC | Internet System for Assessing Autistic Children | 评估自闭症儿童的互联网系统 |
| ISAAC | Indirection, Shift, Accumulate, Add and Count (cryptographic random number generator) | Indirection、Shift、Accumulate、Add和Count（加密随机数生成器） |
| ISAAC | International Symposium on Symbolic and Algebraic Computation | 符号和代数计算国际研讨会 |
| ISAAC | Information Selector and Automatic Copier | 信息选择器和自动复印机 |
| ISAAC | Integrated Systems And Automated Communications | 集成系统和自动化通信 |