| ISLE | Indian Society Of Lighting Engineers | 印度照明工程师协会 |
| ISLE | Integrated Simulation Language Environment | 集成仿真语言环境 |
| ISLE | Information Systems for Law Enforcement | 执法信息系统 |
| ISLE | Isle of Capri Casino | 卡普里岛赌场 |
| ISLE | Integrated Soccer Learning Environment | 综合足球学习环境 |
| ISLE | Informal Science Learning Environment | 非正式科学学习环境 |
| ISLE | Interactive Spoken Language Education | 交互式口语教育 |
| ISLE | Intelligent Speech And Language Environment | 智能语音和语言环境 |