| SME | Society of Manufacturing Engineers | 制造工程师学会[美] |
| SME | Society for Mining Metallurgy and Exploration | 矿冶与探测学会 |
| SME | Short Message Entity | 短消息实体 |
| SME | Solar Mesosphere Explorer | 太阳－地球中层大气探测器 |
| SME | Society of Mining Engineers | 采矿工程师协会 |
| SME | Small and Medium-sized Enterprise | 中小企业 |
| SME | System Management Entity | 系统管理实体 |
| SME | School of Military Engineering | 军事工程学院 |
| SME | Soil and Materials Engineers, Inc (Plymouth, MI) | 土壤与材料工程师公司（密歇根州普利茅斯） |
| SME | Society for Mining, Metallurgy, and Exploration | 采矿、冶金和勘探学会 |
| SME | Solutions Middle East | 中东解决方案 |
| SME | Society of Military Engineers | 军事工程师学会 |
| SME | School of Materials Engineering | 材料工程学院 |
| SME | Static Model Exchange | 静态模型交换 |
| SME | SystÈme MonÉtaire EuropÉen (French: European monetary system) | SystÈme MonÉtaire EuropÉen (French: European monetary system) |
| SME | Signaling Message Encryption | 信令消息加密 |
| SME | Secure Mobile Environment | 安全的移动环境 |
| SME | Sports Media Entertainment (broadcast outlet) | 体育媒体娱乐（广播渠道） |
| SME | Small and Medium Enterprises | 中小型企业 |
| SME | Squadron Medical Element | 中队医疗分队 |
| SME | Shape Memory Effect | 形状记忆效应 |
| SME | Search Marketing Engineer | 搜索营销工程师 |
| SME | Senior Mining Engineer | 高级采矿工程师 |
| SME | Simple Menu Entry | 简单菜单项 |
| SME | State Museum of Ethnography | 国家民族志博物馆 |
| SME | Small or Medium Entreprise | 小型或中型企业 |
| SME | Scale Model Equipment | 比例模型设备 |
| SME | Standard Metropolitan Enterprises | 标准都市企业 |
| SME | Sunflower Methyl Ester | 向日葵甲酯 |
| SME | Sistema Monetario Europeo | 欧洲货币体系 |
| SME | Scale Model Engineering | 比例模型工程 |
| SME | Short Message Encryption | 短消息加密 |
| SME | Sales and Marketing Executives, Inc. | 销售和营销主管有限公司。 |
| SME | Sustaining Membership Enrollment | 持续会员注册 |
| SME | Scout Mountain Equipment | 侦察山地装备 |
| SME | Shopping Made Easy | 轻松购物 |
| SME | State Machine Editor | 状态机编辑器 |
| SME | Standard Model Extension (physics) | 标准模型扩展（物理） |
| SME | Subject Matter Expertise | 主题专业知识 |
| SME | Square Meter Equivalent (textile trade) | 平方米当量（纺织品贸易） |
| SME | Software Management for Executives (training course) | 高管软件管理（培训课程） |
| SME | Spatial Modeling Environment | 空间建模环境 |
| SME | Surface Movement Element | 表面移动元素 |
| SME | Sausage McMuffin with Egg (McDonalds) | 香肠加鸡蛋（麦当劳） |
| SME | Supply Management Executive/Expert | 供应管理行政/专家 |
| SME | Selector Mark Enable | 选择器标记启用 |
| SME | Sales & Marketing Executives International | 销售和营销执行官国际 |
| SME | Shimoga (Indian town railway code) | Shimoga（印度城镇铁路代码） |
| SME | Submucosal Extension | 粘膜下延伸 |
| SME | Sloppy Meateaters (band) | 邋遢的肉食者（乐队） |
| SME | Shape Metal Effect | 形状金属效果 |
| SME | Specialized Market Expert | 专业市场专家 |
| SME | Small or Medium Enterprise | 中小型企业 |
| SME | stalk median eminence | 茎中央隆起 |
| SME | Small and Medium Enterprise | 中小型企业 |
| SME | State of Mississippi Entrepreneurs | 密西西比州企业家 |
| SME | Significant Military Equipment | 重要军事装备 |
| SME | Subject Matter Expert | 主题专家 |
| SME | Synchronous Modem Eliminator | 同步调制解调器消除器 |
| SME | Sales Management Engineer | 销售管理工程师 |
| SME | Systems Maintenance Engineer | 系统维护工程师 |
| SME | Security Message Exchange | 安全消息交换 |
| SME | Solid-Metal Embrittlement | 固体金属脆化 |
| SME | Shape Memory Effect (engineering) | 形状记忆效应（工程） |
| SME | Republic of Surinam (international auto identification) | 苏里南共和国（国际自动识别） |
| SME | Surface Mobile Equipment | 地面移动设备 |
| SME | Small Management Element | 小型管理要素 |
| SME | Stato Maggiore dell'Esercito (Italian: Army General Staff) | 戴尔'Esercito Stato语言(意大利军队的总参谋部) |
| SME | Session Management Engine (software development and testing) | 会话管理引擎（软件开发和测试） |
| SME | Sinorhizobium Meliloti | Meliloti中华根瘤菌 |
| SME | Shawnee Mission East | Shawnee Mission East公司 |
| SME | Senior Management Executive | 高级管理人员 |
| SME | Submucosal Mass Effect | 粘膜下肿块效应 |
| SME | Saami, Northern (Norwegian ISO Language Code) | 北部萨米语（挪威ISO语言代码） |
| SME | Sistema Monetario Europeo (Italian) | Sistema Monetario Europeo（意大利语） |
| SME | Special Minister of the Eucharist | 圣餐特别部长 |