| LESA | Lewis Engineers and Scientists Association | 刘易斯工程师和科学家协会 |
| LESA | Logistics Execution Systems Association | 物流执行系统协会 |
| LESA | limited English-speaking ability | 英语口语能力有限 |
| LESA | Land Evaluation and Site Assessment | 土地评估和现场评估 |
| LESA | Local Environment System Architecture | 本地环境系统架构 |
| LESA | Least Sandpiper (bird species Calidris minutilla) | 最少的鹬(鸟类Calidris minutilla) |
| LESA | Law Enforcement Support Agency (911 dispatch center) | 执法支持机构(911调度中心) |
| LESA | liposomally entrapped second antibody | 脂质体包裹的第二抗体 |
| LESA | Logistics Element Support Activity | 后勤分队支持活动 |
| LESA | Livingston Educational Service Agency | 利文斯顿教育服务机构 |
| LESA | Laboratoire des Études SÉmitiques Anciennes (French) | Laboratoire des Études SÉmitiques Anciennes (French) |
| LESA | low effective specific activity | 低有效比活度 |
| LESA | Landlord's Energy Saving Allowance (UK) | 地主的节约能源的补贴(英国) |
| LESA | Lifestyle Enrichment for Senior Adults (Canada) | 老年人生活方式丰富(加拿大) |
| LESA | Life Event Scale for Adolescents | 青少年生活事件量表 |
| LESA | Lab, Engineering, Sales, & Administration costs | 实验室、工程、销售和管理费用 |