| SPE | specificity | 特异度 |
| SPE | Solar-Energy & Photovoltaic Application Expo | 太阳能光伏应用博览会 |
| SPE | Super Paramagnetic Effect | 超常磁性效应 |
| SPE | Special Purpose Entity | 特殊目的实体 |
| SPE | Stani’s Python Editor | 开放源码的 Python 集成开发环境 |
| SPE | Solid Phase Extraction | 固相萃取 |
| SPE | Society of Professional Engineers | 专业工程师协会 |
| SPE | Society for Photographic Education | 摄影教育协会 |
| SPE | Society for Pure English | 纯英语协会 |
| SPE | serum protein electrophoresis | 血清蛋白电泳 |
| SPE | Society of Petroleum Engineers | 石油工程师学会 |
| SPE | Sauber Petronas Engineering | Sauber Petronas工程 |
| SPE | Software Product Evaluation | 软件产品评估 |
| SPE | Systems Performance Effectiveness | 系统性能有效性 |
| SPE | Society of Plastics Engineers, Inc. | 塑料工程师学会。 |
| SPE | Spacecraft Power Electronics | 航天器电力电子 |
| SPE | South Pit Extension (Project; Australia) | 南矿坑扩建（项目；澳大利亚） |
| SPE | Software Product Expert | 软件产品专家 |
| SPE | Siemens Professional Education (formerly Siemens-Berufsausbildung) | 西门子专业教育（前身为西门子Berufsausbildung） |
| SPE | Small Program Enhancement (IBM) | 小程序增强（IBM） |
| SPE | SociÉtÉ CoopÉrative de Production d'ElectricitÉ (Belgium electric company) | SociÉtÉ CoopÉrative de Production d'ElectricitÉ (Belgium electric company) |
| SPE | Sensor Processing Electronics | 传感器处理电子学 |
| SPE | sucrose polyester | 蔗糖聚酯 |
| SPE | Software Port Entity | 软件端口实体 |
| SPE | Sepulot, Sabah, Malaysia | Sepulot，沙巴，马来西亚 |
| SPE | Service Procurement Engineering | 服务采购工程 |
| SPE | sound pressure energy | 声压能量 |
| SPE | Student Program Element | 学生计划要素 |
| SPE | septic pulmonary edema | 脓毒性肺水肿 |
| SPE | symmetrical progressive erythrokeratoderma | 对称性进行性红角化病 |
| SPE | sustained physical exercise | 持续体育锻炼 |
| SPE | Service Processing Element | 服务处理元素 |
| SPE | Semiconductor Product Equipment | 半导体产品设备 |
| SPE | Saw Palmetto Extract | 锯棕榈提取物 |
| SPE | Special Police Establishment | 特别警察机构 |
| SPE | Service Processing Element (Cisco) | 服务处理元件（Cisco） |
| SPE | Service Platform Engineering | 服务平台工程 |
| SPE | Satellite Precipitation Estimate | 卫星降水量估算 |
| SPE | Services Protected Evacuation | 受保护的疏散服务 |
| SPE | Servicios PÚblicos de Empleo (Spanish) | Servicios PÚblicos de Empleo (Spanish) |
| SPE | SONET Payload Envelope | SONET有效载荷包络 |
| SPE | Stored Program Element (USAF SACCS 465L EDTCC) | 存储程序元素（USAF SACCS 465L EDTCC） |
| SPE | Secondary Particulate Emissions | 次级微粒排放 |
| SPE | Swedish Penis Enlarger (Austin Powers) | 瑞典阴茎扩张器（Austin Powers） |
| SPE | Synergistic Processing Element | 协同处理元件 |
| SPE | Symbolic Programming Environment | 符号编程环境 |
| SPE | Sum of Predicted Error | 预测误差总和 |
| SPE | Software Product Engineering | 软件产品工程 |
| SPE | Software Performance Engineering | 软件性能工程 |
| SPE | Startup Phase Error | 启动阶段错误 |
| SPE | Spherical Probable Error | 球形可能误差 |
| SPE | Solid Phase Epitaxial Regrowth | 固相外延再生长 |
| SPE | Senior Procurement Executive | 高级采购主管 |
| SPE | Subgame Perfect Equilibrium (game theory) | 子博弈完美均衡（博弈论） |
| SPE | SIPRnet Premise Equipment | SIPRnet前提设备 |
| SPE | streptococcal pyrogenic exotoxin | 链球菌热原性外毒素 |
| SPE | Synchronous Payload Envelope | 同步净负荷包封 |
| SPE | Semiconductor Production Equipment | 半导体生产设备 |
| SPE | Solid Phase Epitaxy | 固相外延 |
| SPE | Solar Proton Event | 太阳质子事件 |
| SPE | Synergistic Processor Element | 协同处理器元件 |
| SPE | Solid Particle Erosion | 固体颗粒侵蚀 |
| SPE | Soy Phytoestrogen | 大豆植物雌激素 |
| SPE | Solar Particle Event | 太阳粒子事件 |
| SPE | Sales Per Employee | 每位员工的销售额 |
| SPE | Special Purpose Equipment | 专用设备 |
| SPE | Sony Pictures Entertainment | 索尼影视娱乐 |
| SPE | subtracting pore effect | 减去孔隙效应 |
| SPE | Supervisory Patent Examiner | 监督专利审查员 |
| SPE | Sulfur Polymer Encapsulation | 硫聚合物封装 |
| SPE | Solid Polymer Electrolyte | 固体聚合物电解质 |
| SPE | Sigma Phi Epsilon | Sigma Phi Epsilon公司 |
| SPE | Synergistic Processing Engine | 协同处理引擎 |