| HPE | Heat Pipe Experiment | 热管实验 |
| HPE | hepatic portoenterostomy | 肝门肠吻合术 |
| HPE | Holoprosencephaly | 全脑畸形 |
| HPE | Health Promotion England | 健康促进英格兰 |
| HPE | Histopathology Examination | 组织病理学检查 |
| HPE | History and Physical Examination | 病史和体检 |
| HPE | hed Planet Earth (band) | hed行星地球（波段） |
| HPE | Humble Portal Engine | 简陋门户引擎 |
| HPE | High Performance Estate (Lancia) | 高性能房地产（Lancia） |
| HPE | Health Promotion Education | 健康促进教育 |
| HPE | Hexakis (NF2) Dipropyl Ether | 六（NF2）二丙基醚 |
| HPE | Hope Vale, Queensland, Australia | 澳大利亚昆士兰霍普谷 |
| HPE | High-Power Effects | 高功率效应 |
| HPE | High Performance Environment | 高性能环境 |
| HPE | High Performance Estate | 高性能房地产 |
| HPE | hydrostatic pulmonary edema | 静水性肺水肿 |
| HPE | high permeability edema | 高渗透性水肿 |