| MIKE | Mike Base | 麦克指标 |
| MIKE | Mister \"I Know Everything\" | “我知道一切”先生 |
| MIKE | mass-analyzed ion kinetic energy | 质量分析离子动能 |
| MIKE | Menu Interaction Kontrol Environment | 菜单交互Kontrol环境 |
| MIKE | Mentoring, Inspiration, Knowledge, and Entrepreneurship | 指导、激励、知识和创业 |
| MIKE | Managed Information and Knowledge Environment | 管理信息和知识环境 |
| MIKE | Micro Interpreter for Knowledge Engineering | 知识工程微解释器 |
| MIKE | Mouse Interface Keyboard Emulation | 鼠标界面键盘仿真 |
| MIKE | Monitoring the Illegal Killing of Elephants | 监测非法猎杀大象 |
| MIKE | Minority Intervention and Kidney Education | 少数民族干预与肾脏教育 |
| MIKE | Michael | 迈克尔 |
| MIKE | Meaningless Irrelevant Known Error | 无意义无关已知错误 |
| MIKE | Maryland International Kite Exposition | 马里兰国际风筝博览会 |
| MIKE | Middle Linebacker (football) | 中卫（足球） |