| ESC | Escape | 退出键 |
| ESC | Economic and Social Council | 联合国经济社会理事会 |
| ESC | Sub-Committee on ECOTECH | 经济技术合作分委会 |
| ESC | electronic spark control | 电子点火控制 |
| ESC | electric suspension control system | 电子控制悬架电子控制悬架 |
| ESC | Escape Character | 终止程序字符 |
| ESC | embryonic stem cell | 胚胎干细胞 |
| ESC | scudo | 埃斯库多 |
| ESC | E-commerce based on Community | 基于社区的电子商务 |
| ESC | East Side Clique | 东侧悬崖 |
| ESC | Energy Systems Centre (Australia) | 能源系统中心(澳大利亚) |
| ESC | English-Speaking Caribbean | 英语加勒比语 |
| ESC | Entertainment Service Center (wireless entertainment software) | 娱乐服务中心(无线娱乐软件) |
| ESC | Expeditionary Sustainment Command (Army Modular Logistics unit) | 远征维持司令部(陆军模块化后勤部队) |
| ESC | Estes Satellite & Communications, Inc. | Estes卫星和通讯有限公司 |
| ESC | European Society of Cardiology | 欧洲心脏病学会 |
| ESC | Entomological Society of Canada | 加拿大昆虫学会 |
| ESC | Energy Solutions Center | 能源解决方案中心 |
| ESC | Electrical Safety Committee | 电气安全委员会 |
| ESC | Executive Seminar Center | 高管研讨会中心 |
| ESC | Environmental Science Center | 环境科学中心 |
| ESC | Economic and Social Committee (EU) | 经济和社会委员会(欧盟) |
| ESC | Export Service Center | 出口服务中心 |
| ESC | Engineering Systems and Computing | 工程系统与计算 |
| ESC | Elementary Concepts in Statistics | 统计学的基本概念 |
| ESC | Enhanced Satellite Capability | 增强的卫星能力 |
| ESC | Embedded Systems Conference | 嵌入式系统会议 |
| ESC | Environment Stress Cracking | 环境应力开裂 |
| ESC | Erosion and Sediment Control | 侵蚀和泥沙控制 |
| ESC | European Stroke Conference | 欧洲中风会议 |
| ESC | Extended Static Checking | 扩展静态检查 |
| ESC | Enterprise Security Client | 企业安全客户端 |
| ESC | English-Speaking Countries | 英语国家 |
| ESC | Enhanced Speech Circuit | 增强型语音电路 |
| ESC | Evergreen State College (Washington) | 长青州立学院(华盛顿) |
| ESC | ESCape (PC button) | ESCape(PC按钮) |
| ESC | European Social Charter | 欧洲社会宪章 |
| ESC | Environmental Systems Corporation | 环境系统公司 |
| ESC | Essential Selection Criteria | 基本选择标准 |
| ESC | Enemy Situation Components | 敌情组件 |
| ESC | English School of Canada (Toronto, Canada) | 加拿大英语学校(加拿大多伦多) |
| ESC | Erdos-Strauss Conjecture | Erdos-Strauss猜想 |
| ESC | European Support Centre | 欧洲支持中心 |
| ESC | European Space Conference | 欧洲空间会议 |
| ESC | Economics Society of Calgary (Alberta, Canada) | 卡尔加里经济学会(加拿大阿尔伯塔省) |
| ESC | Evaluation Services Center | 评估服务中心 |
| ESC | Ethnic Student Center | 民族学生中心 |
| ESC | Empire State College (New York) | 帝国州立学院(纽约) |
| ESC | Eldorado Sport Coupe (Cadillac automobile) | 埃尔多拉多跑车(凯迪拉克汽车) |
| ESC | Equilibrator Support Cover | 平衡器支撑盖 |
| ESC | English Sports Council (UK) | 英国体育委员会 |
| ESC | Educational Services Commission | 教育服务委员会 |
| ESC | Escalation Website | 升级网站 |
| ESC | Endangered Species Commission | 濒危物种委员会 |
| ESC | Employment Security Commission | 就业保障委员会 |
| ESC | European Simulation Congress | 欧洲模拟大会 |
| ESC | Equipment Status Chart | 设备状态图 |
| ESC | Electrical Service Center | 电气服务中心 |
| ESC | Engineering Student Council | 工程学生委员会 |
| ESC | Engineering Semiconductor Courses | 工程半导体课程 |
| ESC | Electronic Systems Center | 电子系统中心 |
| ESC | European Society of Criminology | 欧洲犯罪学学会 |
| ESC | Educational Software Cooperative | 教育软件合作社 |
| ESC | Environmental Sustainability Committee | 环境可持续性委员会 |
| ESC | Extended Synchronizing Codeword | 扩展同步码字 |
| ESC | Electronic Speed Control (DC motor) | 电子速度控制(直流电机) |
| ESC | Employment Studies Centre (Australia) | 就业研究中心(澳大利亚) |
| ESC | Elected Staff Council | 民选员工委员会 |
| ESC | Energy Services Coalition | 能源服务联盟 |
| ESC | EISA (Extended Industry Standard Architecture) System Component | EISA(扩展工业标准体系结构)系统组件 |
| ESC | Environmental Safety Center | 环境安全中心 |
| ESC | Endangered Species Coalition (Washington, DC) | 濒危物种联盟(华盛顿特区) |
| ESC | Escudo (Portuguese currency) | 埃斯库多(葡萄牙货币) |
| ESC | Extended Spectrum Capacity | 扩展频谱容量 |
| ESC | Electronic Still Camera | 电子静态照相机 |
| ESC | Earth Science Centre | 地球科学中心 |
| ESC | Evaporative Spray Cooling | 蒸发喷雾冷却 |
| ESC | English Speaking Country | 英语国家 |
| ESC | Express Service Code | 快递服务代码 |
| ESC | Essential Services Commission (Australia) | 基本服务委员会(澳大利亚) |
| ESC | Executive and Supervisory Committee | 执行和监督委员会 |
| ESC | Environmental Steering Committee | 环境指导委员会 |
| ESC | Extra-Statutory Concessions | 额外法定特许权 |
| ESC | Engineering Service Circuit | 工程服务电路 |
| ESC | Escalator | 自动扶梯 |
| ESC | Eurovision Song Contest | 欧洲歌唱大赛 |
| ESC | European Standardisation Committee | 欧洲标准化委员会 |
| ESC | Engineering Support Center | 工程支持中心 |
| ESC | Environmental Stress Cracking | 环境应力开裂 |
| ESC | East Surrey College (UK) | 东萨里学院(英国) |
| ESC | Endangered Species Committee | 濒危物种委员会 |
| ESC | Environmental Support Center | 环境支持中心 |
| ESC | European Shooting Confederation | 欧洲射击联合会 |
| ESC | Endometrial Stromal Cell | 子宫内膜基质细胞 |
| ESC | Education Service Center | 教育服务中心 |
| ESC | École SupÉrieure de Commerce (French) | École SupÉrieure de Commerce (French) |
| ESC | Electronic Service Center | 电子服务中心 |
| ESC | Every Second Counts | 每秒计数 |
| ESC | Employee Service Center | 员工服务中心 |