| SISC | Society for International Space Cooperation | 国际空间合作协会 |
| SISC | SocietÀ Italiana per lo studio delle cefalee (Italian) | SocietÀ Italiana per lo studio delle cefalee (Italian) |
| SISC | Side-Information Source Code | 侧面信息源代码 |
| SISC | Self-Insured Schools of California | 加州自保学校 |
| SISC | Second Interpreter of Scheme Code | 方案代码第二解释程序 |
| SISC | Standard Instruction Set Computing/Computing | 标准的指令集计算/计算 |
| SISC | Simulation Interoperability Standards Committee (standards committee for the IEEE Computer Society) | 模拟互操作性标准委员会（IEEE计算机学会标准委员会） |
| SISC | Simple Instruction Set Chip | 简单指令集芯片 |
| SISC | SSI Status Code | SSI状态代码 |
| SISC | Senate Internal Security Subcommittee | 参议院内部安全小组委员会 |
| SISC | Standard Information Systems Center | 标准信息系统中心 |
| SISC | Semiconductor Interface Specialists Conference | 半导体接口专家会议 |
| SISC | SMils International Summer Camps | SMils国际夏令营 |