| UPI | United Press International | 美国合众国际社 |
| UPI | User Premises Interface | 用户室内接口 |
| UPI | Universitas Pendidikan Indonesia | 印度尼西亚彭迪迪坎大学 |
| UPI | Unique Public Identifier | 唯一公共标识符 |
| UPI | Unwarranted Punishment Of Innovation | 无理惩罚创新 |
| UPI | Universal Product Identification | 通用产品标识 |
| UPI | Useless Piece of Information | 无用的信息 |
| UPI | User Program Interface | 用户程序界面 |
| UPI | Ulkopoliittinen Instituutti (Finnish Institute of International Affairs, Helsinki, Finland) | Ulkopolititten Instituutti（芬兰赫尔辛基芬兰国际事务研究所） |
| UPI | ulteroplacental insufficiency | 胎盘功能不全 |
| UPI | Universal Pensions Incorporated | 环球养老金公司 |
| UPI | uteroplacental ischemia | 子宫胎盘缺血 |
| UPI | Upper Plenum Injection | 上增压室喷射 |
| UPI | Uluslararasi Basin Birligi | Uluslararasi盆地Birligi |
| UPI | United Phreakers Incorporated | 联合Phreakers公司 |
| UPI | Unocal Philippines, Inc (formerly Philippine Geothermal, Inc) | 优尼科菲律宾公司（前菲律宾地热公司） |
| UPI | UniÓn Profesional InformÁtica | UniÓn Profesional InformÁtica |
| UPI | Uteroplacental Insufficiency (pregnancy risk factor) | 子宫胎盘功能不全（妊娠危险因素） |
| UPI | Unione Delle Province d'Italia (Union of the Province of Italy; benevolent group) | Unione联盟('Italia阿尔省d省的慈善团体)的意大利 |
| UPI | Unpaid Item (eBay) | 未付款项目（易趣） |
| UPI | User Payload Identifier | 用户有效载荷标识符 |
| UPI | Unique Patient Identifiers (HIPAA) | 唯一患者标识符（HIPAA） |
| UPI | University Physicians Inc. | 大学医生公司。 |
| UPI | Unidentified Party Injury | 身份不明的当事人伤害 |