| RISC | Reduced Instruction Set Computing | 精简指令集计算机 |
| RISC | Rental Industry Secure Customer | 租赁行业安全客户 |
| RISC | RISCORP, Inc. | RISCORP公司。 |
| RISC | Reality In Seeking Christ | 寻找基督的现实 |
| RISC | Reduced Instruction Set Compiling | 精简指令集编译 |
| RISC | Research Group on Instability in Coronary Artery Disease | 冠状动脉疾病不稳定性研究小组 |
| RISC | Reduced Instruction Set Computer | 精简指令集计算机 |
| RISC | Risk Information Support Center | 风险信息支持中心 |
| RISC | Runway Incursion Severity Classification (ICAO) | 跑道撞击严重程度分类（ICAO） |
| RISC | Reduced Instruction Set Code | 精简指令集代码 |
| RISC | Regional Intelligence Support Center | 区域情报支持中心 |
| RISC | Radiology Information System Consortium | 放射信息系统联盟 |
| RISC | Rhode Island Striper Club | 罗德岛脱衣舞俱乐部 |
| RISC | Rural Industries Service Centre (India) | 农村工业服务中心（印度） |
| RISC | Repository for Individuals of Special Concern (US FBI) | 特别关注个人资料库（美国联邦调查局） |
| RISC | RNA Induced Silencing Complex (ribonucleoprotein complex involved in mRNA degradation) | RNA诱导沉默复合物（参与mRNA降解的核糖核蛋白复合物） |
| RISC | Regional Interagency Steering Committee (FEMA/Federal Response Plan) | 区域内部督导委员会(FEMA /联邦反应计划) |
| RISC | Responsible Internet Service Companies | 负责任的互联网服务公司 |
| RISC | Risk Information Sharing Consortium (National League of Cities) | 风险信息共享联盟（国家城市联盟） |
| RISC | Risk Institute for the Support of Communication | 通信支持风险研究所 |
| RISC | Reduced Instruction Set Class | 精简指令集类 |
| RISC | Research Institute for Symbolic Computation (Linz, Austria) | 符号计算研究所（奥地利林茨） |
| RISC | Regulatory Information Service Center (OMB) | 监管信息服务中心（OMB） |
| RISC | Research And Information Support Center | 研究和信息支持中心 |