| OSF | Open Software Foudation | 开放软件基金 |
| OSF | Obtain Service From | 从获取服务 |
| OSF | Open Systems Foundation | 开放系统基础 |
| OSF | Operational Support Facility | 作战支援设施 |
| OSF | Oxidation-induced Stacking Fault | 氧化导致的堆积断层 |
| OSF | Other Structures and Facilities | 其他结构和设施 |
| OSF | Open Software Foundation | 开放软件基础 |
| OSF | Ordnance Storage Facility | 军械储存设施 |
| OSF | Operations Support Flight | 作战支援飞行 |
| OSF | Office of Space Flight | 航天飞行办公室 |
| OSF | Offset Field | 偏移字段 |
| OSF | Organizational Structure Facility | 组织结构设施 |
| OSF | Occupiable Square Feet | 可占用面积（平方英尺） |
| OSF | Office of Strategic Finance | 战略财务办公室 |
| OSF | Oil Stabilization Fund | 石油稳定基金 |
| OSF | Congregation of Servants of Holy Infancy Jesus (religious order) | 圣婴耶稣仆人大会（宗教秩序） |
| OSF | Open Software Forum | 开放软件论坛 |
| OSF | Omega Sector Fleetyards (Halo gaming) | Omega Sector Fletyards（光环游戏） |
| OSF | Oversubscription Factor (Cisco) | 超额认购系数（Cisco） |
| OSF | Franciscan Brothers or Sisters (religious order) | 方济各会兄弟姐妹（宗教秩序） |
| OSF | Outrage Sound Format | 愤怒的声音格式 |
| OSF | Open Source Folks | 开源民间团体 |
| OSF | Oregon Shakespeare Festival | 俄勒冈莎士比亚戏剧节 |
| OSF | Ordinis Sancti Francisci (of the order of St Francis) | Ordinis Sancti Francisci（圣方济各勋章） |
| OSF | Oyster Strike Force | 牡蛎攻击力 |
| OSF | Orthoptera Species File | 直翅目物种文件 |
| OSF | Ordered Statistics Filter | 有序统计筛选器 |
| OSF | Old Style Figures | 旧式人物 |
| OSF | Office Systems Family | Office系统系列 |
| OSF | outer spiral fibers | 外螺旋纤维 |
| OSF | Operations System Function (ANSI) | 操作系统功能（ANSI） |
| OSF | overgrowth stimulating factor | 过度生长刺激因子 |
| OSF | On-Site Familiarization | 现场熟悉程度 |
| OSF | Operation Support Facility | 运营支持设施 |
| OSF | Oregon Shakespeare Festival (Ashland, Oregon) | 俄勒冈州莎士比亚节（俄勒冈州阿什兰） |
| OSF | Order Of Saint Francis | 圣方济各勋章 |
| OSF | Old Spaghetti Factory (US restaurant chain) | 老意大利面工厂（美国连锁餐厅） |
| OSF | Object Strike Force | 物体打击力 |
| OSF | Order Of St Francis | 圣弗朗西斯勋章 |
| OSF | Operational Support Facility ( Orlando) | 运营支持设施（奥兰多） |
| OSF | Optimal Solutions Found | 找到最佳解决方案 |
| OSF | Osaka Stock Futures 50 | 大阪股票期货50 |
| OSF | Observed Support Frequency | 观察到的支持频率 |