| SPO | Sociedade Portuguesa de Ovnilogia (Portuguese Society for Research and Communication of Knowledge concerning UFO) | 葡萄牙UFO知识研究与传播协会 |
| SPO | Senior Programme Officer | 高级方案干事 |
| SPO | Space Program Office | 太空计划办公室 |
| SPO | Special Project Officer | 特别项目官员 |
| SPO | Serviço de Psicologia e Orientação | Serviço de Psicologia e Orientação |
| SPO | Sausage Peppers and Onions | 香肠辣椒和洋葱 |
| SPO | Special Order (used in retail stores operation) | 特殊订单（用于零售店运营） |
| SPO | Sponsored Projects Officer | 赞助项目官员 |
| SPO | Systematic Payout | 系统性支出 |
| SPO | Safety Project Office | 安全项目办公室 |
| SPO | Sacramento Peak Observatory (Sunspot, NM) | 萨克拉门托峰天文台（北卡罗来纳州太阳黑子） |
| SPO | Specific Personal Objective | 具体个人目标 |
| SPO | Software Product Outsourcing | 软件产品外包 |
| SPO | Seoul Philharmonic Orchestra | 首尔爱乐乐团 |
| SPO | Spacelab Projects Office (NASA) | 太空实验室项目办公室（NASA） |
| SPO | Sheffield Philharmonic Orchestra (UK) | 谢菲尔德爱乐乐团（英国） |
| SPO | Summit Planning Organization | 峰会规划组织 |
| SPO | Strategic Performance Objectives | 战略绩效目标 |
| SPO | Sarajevo Philharmonic Orchestra | 萨拉热窝爱乐乐团 |
| SPO | Shortest Path Oblivious (optical networking algorithm) | 最短路径不可见（光网络算法） |
| SPO | Secondary Public Offering | 二次公开发行 |
| SPO | State Planning Office | 国家规划办公室 |
| SPO | State Procurement Office | 国家采购办公室 |
| SPO | South Pole Observatory | 南极天文台 |
| SPO | Special Palm Oil | 特殊棕榈油 |
| SPO | Space Pirate Organization | 太空海盗组织 |
| SPO | Spokane, Washington | 华盛顿州斯波坎 |
| SPO | Sign Performance Outreach | 签署绩效外联 |
| SPO | System Project Office | 系统项目办公室 |
| SPO | stimulated pepsin output | 刺激胃蛋白酶输出 |
| SPO | spondweni virus | 辛迪维尼病毒 |
| SPO | Sponsored Projects Office | 赞助项目办公室 |
| SPO | Super Production Over | 超级生产结束 |
| SPO | Security, Plans, and Operations | 安全、计划和运营 |
| SPO | Security and Plans Officer | 安全和计划干事 |
| SPO | Special Project Office | 特殊项目办公室 |
| SPO | Small Pack Option | 小型包装选项 |
| SPO | serving post office | 在职邮局 |
| SPO | Shanghai Philharmonic Orchestra | 上海爱乐乐团 |
| SPO | Support Operations Officer | 支持运营官 |
| SPO | Special Program Office/Officer | 特殊项目办公室/军官 |
| SPO | Security Police Officer | 治安警察 |
| SPO | Shape Preferred Orientation | 形状首选方向 |
| SPO | Security and Plans Office/Officer | 安全计划办事处/军官 |
| SPO | Sub Post Office | 邮政分局 |
| SPO | Social Policy Obligations | 社会政策义务 |
| SPO | Security and Protection Officer | 安保和保护干事 |
| SPO | Service Platform Operations (Sprint) | 服务平台运营（Sprint） |
| SPO | Security Payment Order | 安全付款单 |
| SPO | Sphincter-Preserving Operation (rectal surgery procedure) | 括约肌保存手术（直肠手术） |
| SPO | Signal Property Office | 信号财产办公室 |
| SPO | Slaithwaite Philharmonic Orchestra (UK) | Slaithwaite爱乐乐团（英国） |
| SPO | Super Pimp Online | 超级皮普在线 |
| SPO | Srpski Pokret Obnove (Serbian: Serbian Renewal Movement; political party created in 1990 in Serbia-Yugoslavia) | Srpski Pokret Obnove（塞尔维亚语：塞尔维亚复兴运动；1990年在塞尔维亚-南斯拉夫成立的政党） |
| SPO | Surrey Philharmonic Orchestra (UK) | 萨里爱乐乐团（英国） |
| SPO | Special Projects Office | 特殊项目办公室 |
| SPO | System(s) Project Office | 系统项目办公室 |
| SPO | Service Provision Option | 服务提供选项 |
| SPO | Slovak Philharmonic Orchestra | 斯洛伐克爱乐交响乐乐团 |
| SPO | Scarborough Philharmonic Orchestra (Canada) Scarborough Philharmonic Orchestra Scarborough Philharmonic Orchestra (Canad | 斯卡伯勒爱乐乐团（加拿大）斯卡伯勒爱乐乐团斯卡伯勒管弦乐团（加拿大 |
| SPO | Saint Paul's Outreach | 圣保罗的延伸 |
| SPO | Special Police Officer | 特别警官 |
| SPO | Stop Payment Order | 停止付款订单 |
| SPO | Shimizu Philharmonic Orchestra | 清水爱乐乐团 |
| SPO | Single-Periodic Oscillation | 单周期振荡 |
| SPO | Security and Plans Operations | 安全和计划运营 |
| SPO | Sagamihara Philharmonic Orchestra | 相模原爱乐乐团 |
| SPO | System(s) Program Office | 系统计划办公室 |
| SPO | Sourcing Process Outsourcing (business process outsourcing of candidate research services) | 采购流程外包（候选研究服务的业务流程外包） |
| SPO | Sendai Philharmonic Orchestra | 仙台爱乐乐团 |
| SPO | Service Parts Operations (General Motors) | 维修零件操作（通用汽车） |
| SPO | Section Panel Operator | 区段面板操作员 |
| SPO | Solar Polar Orbiter | 太阳极轨道器 |
| SPO | Seminary Post Office | 神学院邮局 |
| SPO | Systematic Payout Option | 系统支付选项 |
| SPO | Sales Promotion Office | 销售推广办公室 |