| NLE | Niles, Michigan (Airport Code) | 密歇根州奈尔斯（机场代码） |
| NLE | Niles, Michigan USA | 尼尔斯，美国密歇根州 |
| NLE | Network-Layer Encryption | 网络层加密 |
| NLE | National Library for the Environment | 国家环境图书馆 |
| NLE | Non Linear Editing (video editing) | 非线性编辑（视频编辑） |
| NLE | Non Linear Editing | 非线性编辑 |
| NLE | National Latin Exam | 全国拉丁语考试 |
| NLE | National Library of Education | 国家教育图书馆 |
| NLE | No Longer Employed | 不再受雇 |
| NLE | Not Less or Equal | 不小于或等于 |
| NLE | norleucine | 去亮氨酸 |
| NLE | neonatal lupus erythematosus | 新生儿红斑狼疮 |
| NLE | National Level Enclave | 国家级飞地 |
| NLE | National LAN Exchange | 国家局域网交换机 |
| NLE | Network-Layer Encryption (Cisco) | 网络层加密（Cisco） |
| NLE | Network Logistics Engineering | 网络物流工程 |
| NLE | Normal Loss Expectancy (insurance) | 正常预期损失（保险） |
| NLE | Non Linear Editor | 非线性编辑器 |
| NLE | Networked Learning Environment | 网络学习环境 |
| NLE | Necrotizing Leukoencephalitis | 坏死性白细胞脑炎 |
| NLE | New Leader Essentials (boy scouting) | 新领袖必备（童子军） |