| COF | Chip On FPC | 将IC固定于柔性线路板 |
| COF | Coefficient of friction | 摩擦系数 |
| COF | Ciphering Offset | 加密补偿 |
| COF | Certificate of Fitness | 健康证明书 |
| COF | Columbus Orbital Facility | 哥伦布轨道设施 |
| COF | Chip-on-Flex | Flex上的芯片 |
| COF | Chamber of Fear | 恐惧室 |
| COF | Central Operations Facility | 中央运营设施 |
| COF | Common Output File | 通用输出文件 |
| COF | Cost of Funds | 资金成本 |
| COF | Customer Order Fulfillment | 客户订单履行 |
| COF | Crabby Old Fart | 古怪的老屁孩 |
| COF | Colleges of the Fenway (since 1996; Boston, Massachusetts) | 芬威学院（自1996年起；马萨诸塞州波士顿） |
| COF | Committee on Faculty | 教师委员会 |
| COF | Church of Freethought | 自由思想教会 |
| COF | Computing Operations Fundamentals (from BOFH) | 计算操作基础（来自BOFH） |
| COF | Council On Foundations | 基金会理事会 |
| COF | Cradle Of Filth | 淫秽摇篮 |
| COF | Cradle of Filth (band) | 污秽摇篮（乐队） |
| COF | Cavazzoni Orlando e Fratello (Italian ice cream) | Cavazzoni Orlando e Fratello（意大利冰淇淋） |
| COF | Centro de OrientaciÓn Femenina (Guatemala) | Centro de OrientaciÓn Femenina (Guatemala) |
| COF | Crazy Old Fart | 疯狂的老屁孩 |
| COF | Catholic Order of Foresters (Catholic fraternal insurance organization founded in 1883; Naperville, IL) | 天主教森林骑士团（1883年成立的天主教兄弟保险组织；伊利诺伊州纳珀维尔） |
| COF | Cloak of Flames (Everquest game) | 火焰斗篷（Everquest游戏） |
| COF | Columbus Operating Facility | 哥伦布运营设施 |
| COF | cobra factor | 眼镜蛇因子 |
| COF | composition of food | 食品成分 |
| COF | cut-off frequency | 截止频率 |
| COF | Channel Output Feedback | 通道输出反馈 |
| COF | Chip on Film | 胶片上的芯片 |
| COF | Covered Offshore Facility | 承保离岸设施 |
| COF | Company Operations Facility | 公司运营设施 |
| COF | Construction Of Facility | 设施建设 |
| COF | Cross Of Fire | 火之十字架 |
| COF | Capital One Financial (stock symbol) | Capital One Financial（股票符号） |
| COF | Council of Fellows | 研究员理事会 |
| COF | Chariots of Fire (movie) | 火战车（电影） |
| COF | Officers' Christian Fellowship of the USA | 军官团契的美国 |
| COF | Capital One Financial Corporation | 第一资本金融公司 |
| COF | College Opportunity Fund | 大学机会基金 |
| COF | Classroom Of the Future | 未来的课堂 |
| COF | Confidence of Fit (trend line) | 拟合置信度（趋势线） |
| COF | Civilian Objective Force | 民用目标部队 |
| COF | Central Operating Facilities | 中央运营设施 |
| COF | County Operated Facility | 县运营设施 |
| COF | Canadian Orienteering Federation | 加拿大定向运动联合会 |
| COF | conduct of fire (US DoD) | 开火（美国国防部） |
| COF | Cofidis - Credit par Telephone (Tour de France cycling sponsor) | Cofidis-Credit par Telephone（环法自行车赛赞助商） |
| COF | College of Fisheries | 渔业学院 |
| COF | Castle of Fun (WOTC message boards) | 娱乐城堡（WOTC留言板） |
| COF | Cup Of Fungus | 真菌杯 |
| COF | Center of Flotation (hull design) | 浮选中心（船体设计） |
| COF | Confirmation Order Form | 确认订单表 |