| SSSS | Satellite Strategic Surveillance System | 卫星战略监视系统 |
| SSSS | Steware & Stevenson Services | Steware和史蒂文森的服务 |
| SSSS | Small Satellites Systems and Services | 小型卫星系统和服务 |
| SSSS | Super Sonic Samba School | 超音速桑巴学校 |
| SSSS | Software Suitability Supportability Statement | 软件适用性支持性声明 |
| SSSS | Stainless Steel Scatter Shield | 不锈钢散射屏 |
| SSSS | Society for the Scientific Study of Sexuality | 性科学研究学会 |
| SSSS | Students for Saving Social Security | 学生储蓄社会保障 |
| SSSS | Scandinavian Simvastatin Survival Study | 斯堪的纳维亚辛伐他汀生存研究 |
| SSSS | State Swim Swimming School (Australia) | 州立游泳学校（澳大利亚） |
| SSSS | staphylococcal scalded skin syndrome | 葡萄球菌烫伤皮肤综合征 |
| SSSS | Space Shuttle System Specification | 航天飞机系统规范 |
| SSSS | Society for Social Studies of Science | 科学社会研究学会 |
| SSSS | Stop Being So Stupid | 别傻了 |
| SSSS | Selected for Special Security Screening (Transportation Security Administration code) | 选择进行特殊安全检查（运输安全管理代码） |