| SPA | Sale and Purchase Agreement | 购销合同 |
| SPA | SOLUS PAR AQUA | 健康在水中 |
| SPA | Software Process Assessment | 软件过程评估 |
| SPA | Spondyloarthritis | 脊柱关节炎 |
| SPA | single point of access | 单一访问点 |
| SPA | Software Publishers Association | 软件出版商协会 |
| SPA | sudden phase anomalies | 突现相位异常，（空间波）相位的突变 |
| SPA | superregeneration parametric amplifier | 超再生参量放大器 |
| SPA | standard practice amendment | 标准作法修正 |
| SPA | substitute part authorization | 替换零件核准 |
| SPA | Software Publishers Association (now SIIA) | 软件出版商协会（现为SIIA） |
| SPA | Seafood Products Association (Seattle, WA) | 海鲜制品协会（华盛顿州西雅图） |
| SPA | Summit Pathology Associates (Akron, OH) | Summit病理学协会（俄亥俄州阿克伦） |
| SPA | Society for Personality Assessment | 人格评估协会 |
| SPA | Social Policy Association (UK) | 社会政策协会（英国） |
| SPA | Sociedade Portuguesa de Autores (Portugal) | 葡萄牙汽车协会（葡萄牙） |
| SPA | Software Piracy Association | 软件盗版协会 |
| SPA | Society of Professional Accountants | 专业会计师协会 |
| SPA | SocietÀ Per Azioni (Italian: shared company) | SocietÀ Per Azioni (Italian: shared company) |
| SPA | Single Point of Access (AT&T) | 单点(AT&T) |
| SPA | Spanish (language) | 西班牙语（语言） |
| SPA | Special Protection Area | 特殊保护区 |
| SPA | Signal Processing Algorithms, Architectures, Arrangements and Applications (conference) | 信号处理算法、架构、安排和应用（会议） |
| SPA | SSCC POSIX APIs (NASA) | SSCC POSIX API（NASA） |
| SPA | Special Project Assignments | 特殊项目任务 |
| SPA | Special Pricing Agreement | 特殊定价协议 |
| SPA | Socialist Party of Albania | 阿尔巴尼亚社会党 |
| SPA | Saddlepoint Approximation | 鞍点近似 |
| SPA | Strategic Planning Application | 战略规划应用 |
| SPA | scintillation proximity assay | 闪烁邻近测定 |
| SPA | sperm penetration assay | 精子穿透试验 |
| SPA | Software Product Assurance | 软件产品保证 |
| SPA | Saudi Press Agency | 沙特通讯社 |
| SPA | Sanus Per Aquam (Latin: health through water) | Sanus Per Aquam（拉丁语：通过水实现健康） |
| SPA | Share Purchase Agreement | 股份购买协议 |
| SPA | Safe Plan of Action (UK) | 安全行动计划（英国） |
| SPA | Simple Power Analysis | 简单功率分析 |
| SPA | Suspended Plate Antenna | 悬挂式平板天线 |
| SPA | Secure Password Authentication | 安全密码验证 |
| SPA | Single Packet Authorization | 单数据包授权 |
| SPA | Strategic Posture Analysis | 战略态势分析 |
| SPA | Submarine Patrol Area | 潜艇巡逻区 |
| SPA | Sheep Pulmonary Adenomatosis | 绵羊肺腺瘤病 |
| SPA | single page application (web pages) | 单页应用程序（网页） |
| SPA | Synthetic Parallel Application | 合成并行应用 |
| SPA | Society for Personnel Administration | 人事管理学会 |
| SPA | Self Propelled Artillery | 自行火炮 |
| SPA | Service Package Application | 服务包应用程序 |
| SPA | Students for Political Action (Ontario, Canada) | 政治行动学生（加拿大安大略省） |
| SPA | Soft Physical Address | 软物理地址 |
| SPA | Single Person Accountability | 单人责任制 |
| SPA | Servo Power Amplifier | 伺服功率放大器 |
| SPA | Source Prescription Audit | 源处方审核 |
| SPA | Senior Police Advisor | 高级警务顾问 |
| SPA | Security Process Algebra | 安全过程代数 |
| SPA | Single Piece Anode | 单片阳极 |
| SPA | Shared Port Adaptor (Cisco) | 共享端口适配器（Cisco） |
| SPA | SOSUS Probability Area | SOSUS概率区域 |
| SPA | Stochastic Prosesses and their Applications (peer reviewed journal) | 随机过程及其应用（同行评审期刊） |
| SPA | Standard Peak Area (gas chromatography) | 标准峰面积（气相色谱法） |
| SPA | Sierra Pacific Tours | Sierra Pacific旅游 |
| SPA | Sectored Phased Array Antenna | 扇形相控阵天线 |
| SPA | Scanner Power Assembly | 扫描仪电源组件 |
| SPA | Special Programme on AIDS (now Global Programme on AIDS) | 艾滋病特别方案（现为全球艾滋病方案） |
| SPA | Sanctuary Preservation Area | 保护区保护区 |
| SPA | Service Provision Assessment | 服务提供评估 |
| SPA | Special Power of Attorney | 特别授权书 |
| SPA | South Pole-Aitken (Basin) | 南极Aitken（盆地） |
| SPA | School of Planning and Architecture (India) | 规划与建筑学院（印度） |
| SPA | Successive Parallel Arbitrated (decision feedback mechanism) | 连续并行仲裁（决策反馈机制） |
| SPA | Surinaamse Partij van de Arbeid (Suriname Labor Party) | 苏里南劳动党 |
| SPA | Secure Platform Architecture (HP-Compaq) | 安全平台体系结构（HP Compaq） |
| SPA | Simplified Purchase Agreement | 简化采购协议 |
| SPA | Special Purchase Allowance | 特殊采购津贴 |
| SPA | Service Performance Assurance | 服务性能保证 |
| SPA | Patriotic Movement of Sint Maarten (Netherlands Antilles) | 圣马丁岛爱国运动（荷属安的列斯群岛） |
| SPA | Society for Pediatric Anesthesia | 小儿麻醉学会 |
| SPA | System Performance Assessment | 系统性能评估 |
| SPA | Single Power Analysis (cryptographic attack) | 单功率分析（密码攻击） |
| SPA | Systems & Process Assurance (PricewaterhouseCoopers, LLP) | 系统及过程,保证公司) |
| SPA | Senior Policy Advisor | 高级政策顾问 |
| SPA | Special Prorate Agreement (airlines fares agreement) | 特殊比例协议（航空公司票价协议） |
| SPA | SCSI Peripheral Adapter | SCSI外围适配器 |
| SPA | Supporting Professionalism in Admissions (UK education) | 支持入学专业化（英国教育） |
| SPA | Saludis Per Aqua (Latin: Health Through Water) | Saludis Per Aqua（拉丁语：通过水的健康） |
| SPA | Single Parent Adoption | 单亲收养 |
| SPA | Square Patch Antenna | 方形贴片天线 |
| SPA | Special Planning Area (planning and development) | 特别规划区（规划和开发） |
| SPA | Shekijah Preparation Assembly (interdenominational church in Lynchburg, VA) | Shekijah预备大会（弗吉尼亚州林奇堡的跨教派教堂） |
| SPA | Shanghai Prison Administration | 上海市监狱管理局 |
| SPA | Supreme People's Assembly (North Korea) | 最高人民大会(朝鲜) |
| SPA | SociÉtÉ Protectrice des Animaux (French: Protective Company of Animals) | SociÉtÉ Protectrice des Animaux (French: Protective Company of Animals) |
| SPA | Saint Paul Academy | 圣保罗学院 |
| SPA | Small Payload Attachment | 小型有效负载附件 |
| SPA | Sampling Probe Algorithm | 采样探针算法 |
| SPA | Scalable Processing Architecture | 可扩展处理体系结构 |
| SPA | Signaling Point Adjunct | 信号点附件 |
| SPA | Spaces Per Aircraft | 每架飞机的空间 |
| SPA | Student Progress and Achievement | 学生进步和成就 |
| SPA | Single Point Accountability | 单点责任制 |